The CSC hypothesis has important clinical implications for cancer therapeutics because of the suggested role of CSCs in chemoresistance (Kakarala and Wicha, 2008). There is increasing evidence that CSCs are naturally resistant to chemotherapy on account of their quiescence, more efficient DNA repair, resistance to apoptosis and expression of drug-resistance proteins, such as ATP-binding cassette transporters (ABCG2 and ABCG5) and multidrug-resistance protein 1 transporters (Dean et al, 2005). If this is correct, a small population of chemoresistant CSCs may resist killing by conventional chemotherapy, whereas majority of tumour cells, which are differentiated cells that lack ‘stemness’, may be killed. The tumour could, therefore, regrow after chemotherapy because of the capacity for self-renewal of these CSCs.
Epigenetic disregulation. This claim uses research into the mechanism of epigenetics to understand how mutations in the epigenetic machinery of cells will altered histone acetylation patterns to create cancer epigenetics. DNA damage appears to be the primary underlying cause of cancer. If DNA repair is deficient, DNA damage tends to accumulate. Such excess DNA damage can increase mutational errors during DNA replication due to error-prone translesion synthesis. Excess DNA damage can also increase epigenetic alterations due to errors during DNA repair. Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms).
Chickweed is an annual herb that can be found all over the world in temperate as well as arctic regions. An interesting characteristic of the chickweed is that it sleeps, at night the leaves will fold up covering the young buds and shoots. Chickweed is also known for being quite a nutritious herb and is a good choice to include in your salads. The whole plant can be used both dried and fresh in herbal remedies. Let's have a look at the main medicinal uses now that this herb is best know for.
Native Americans and Traditional Chinese Medicine (TCM) use this common weed as a great digestive tonic and bladder curative. Dandelion (Taraxacum officinale) helps stimulate the kidneys to increase urine production, which helps flush out your urinary tract. Dandelion tea is also used for maintaining healthy blood sugar levels and often referred to an anti-diabetic plant and anti-hyperglycemic. It is also used as a treatment for atherosclerosis.
Generally garlic is safe when taken in a regular diet. There is a small risk that can occur however when eating large doses of garlic daily, taking more than 4 cloves per day can affect the bodies platelets hindering them from forming clots. You should reduce use of garlic around 2 weeks before having any type of surgery and if you're taking anticoagulant medications.
Rumex crispus Curly dock or yellow dock In Western herbalism the root is often used for treating anemia, due to its high level of iron. The plant will help with skin conditions if taken internally or applied externally to things like itching, scrofula, and sores. It is also used for respiratory conditions, specifically those with a tickling cough that is worse when exposed to cold air. It mentions also passing pains, excessive itching, and that it helps enlarged lymphs.
Yes. When taking medication, you should investigate possible interactions with an herbal remedy you may be considering. Be careful about mixing herbs and drugs that have similar actions. For example, it may not be a good idea to mix anticoagulant drugs with ginkgo, a natural blood thinner; the herb valerian, a sedative, probably shouldn’t be mixed with prescription sleeping pills. Similarly, avoid mixing herbs and drugs that have opposite actions. Other agents may alter the way a medication is handled by the body. For example, St. John’s wort, a natural remedy for depression, may reduce the effectiveness of some drugs by causing them to be metabolized too quickly. When in doubt, check with your pharmacist about herb/drug interactions. In addition, herbs that can thin blood, such as dong quai, feverfew, supplemental garlic, and ginger could cause problems if taken before surgery as could herbs such as ginseng and licorice root that affect heart rate and blood pressure. Sedative herbs like kava and valerian may increase the effects of anesthesia. It is best to stop taking any of these herbs at least 10-14 days before surgery, and be sure to tell your physician that you’ve been taking them.
Known for its immune-boosting and disease-fighting benefits, this Chinese herb has several positive diabetes studies behind it. Researchers have found that ginseng slows carbohydrate absorption; increases cells’ ability to use glucose; and increases insulin secretion from the pancreas. A team from the University of Toronto has repeatedly demonstrated that ginseng capsules lower blood glucose 15 to 20 percent compared to placebo pills. These are the best superfoods for people with diabetes.
Peppermint leaves are well known for their healing properties. Menthol in peppermint soothes the throat and acts as a decongestant, helping to break down mucus. You can benefit by drinking peppermint tea or by inhaling peppermint vapors from a steam bath. To make a steam bath, add 3 or 4 drops of peppermint oil for every 150 milliliters of hot water. Drape a towel over your head, and take deep breaths directly above the water.
A dry, hacking, cough is another story. This is one we do want to stop. It can be caused by allergies, dry air, a random tickle at the back of your throat that won’t go away, the aftermath of a cold, being in a dusty environment, etc. etc. For these we turn to demulcents, ingredients that soothe irritated mucous membranes and remove the irritant triggering the cough. Studies conducted in 2004 found that the main ingredients in cough syrup (dextromethorphan and diphenhydramine) have the same effectiveness in treating coughs as a placebo ingredient. Instead of turning to chemical solutions for every minor ailment, try some home remedies instead. They are not only better for you, but they taste a whole lot better than most cough syrup too!
Ashwagandha is sometimes called “Indian ginseng” as it has many similar health properties. This herb is very popular in the Ayurvedic system of health in India. It is considered an adaptogen. It is commonly used to relieve stress and strengthen the immune system. It has the ability to strengthen the body and increase endurance. This herb has been used in India for over 3,000 years as a rejuvenator. The seeds of this plant are thought to have a diuretic effect, while the leaves possess anti-inflammatory, analgesic and sedative properties. The chemical components of the root have anti-microbial, anti-inflammatory, analgesic, immune strengthening and sedative properties. This is a great herb for athletes and active people that need to increase their energy, strength and stamina.
Maintaining normal blood sugar levels is necessary for the body’s overall health. Erratic blood sugar levels can affect the body’s ability to function normally and even lead to complications if left unchecked. Some herbs and spices found in nature do a tremendous job of naturally lowering blood sugar levels, making them a boon for diabetics and pre-diabetics. What’s more, being nature’s multi-taskers, herbs and spices also produce overall health benefits beyond just helping balance blood sugar.
This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.